Cyclobenzaprine: Uses, Interactions, Mechanism of Action DrugBank Online

The elderly may also be more at risk for CNS adverse events such as hallucinations and confusion, cardiac events resulting in falls or other sequelae, drug-drug and drug-disease interactions. For these reasons, in the elderly, cyclobenzaprine should be used only if clearly needed. In such patients FLEXERIL should be initiated with a 5 mg dose and titrated slowly upward. Clinicians should monitor for signs and symptoms of serotonin syndrome if the patient is taking other serotonergic drugs.

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This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here. Talk with your doctor about other drug options that may work for you. As with all medications, the costs of cyclobenzaprine can vary.

Cyclobenzaprine Hydrochloride

Based on individual patient response, the dose may be increased to 10 mg three times a day. Use of FLEXERIL for periods longer than two or three weeks is not recommended. Cyclobenzaprine is structurally and pharmacologically related to tricyclic antidepressants. Among the most dreaded toxicities linked with cyclical antidepressants, overdoses affect fast-acting sodium channels in the cardiac conduction system. Cyclical antidepressants block the cardiac sodium channel and cause prolongation of cardiac depolarization, which manifests as QRS widening on electrocardiograms.

There are very few drugs with minor Cyclobenzaprine interactions. These include Modafinil, Armodafinil, Atazanavir, Donepezil, Dimenhydrinate, the Ipratropium nasal spray, and the Evening Primrose plant that is used in alternative medicine. The interactions of Cyclobenzaprine with these drugs are deemed safe as there is but a small, unlikely, and minimal risk of adverse outcome. Drowsiness, dizziness, dry mouth, constipation, or tiredness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Some facilities also include step-down levels of care to include a partial hospitalization program or an intensive outpatient program.

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Because cyclobenzaprine is closely related to the tricyclic antidepressants, some of which are known to be excreted in human milk, caution should be exercised when FLEXERIL is administered to a nursing woman. Less frequent dosing should be considered for hepatically impaired or elderly patients (see PRECAUTIONS, Impaired Hepatic Function, and Use in the Elderly). Our Flexeril (cyclobenzaprine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. You can call (or for the deaf and the hard of hearing) to talk to a pharmacist about your medication questions. Our pharmacists are available by phone every night from 5pm to 9am – when your community pharmacist may be unavailable. Please call our 24-hour hotline listed above if you need information about treatment for addiction to Flexeril or alcohol for yourself or for a loved one.

OVERDOSE

One study compared FLEXERIL 5 mg and 10 mg t.i.d. to placebo; and a second study compared FLEXERIL 5 mg and 2.5 mg t.i.d. to placebo. Primary endpoints for both trials were determined by patient-generated data and included global impression of change, medication helpfulness, and relief from starting backache. Each endpoint consisted of a score on a 5-point rating scale (from 0 or worst outcome to 4 or best outcome).

In children 2 to 7 years old, the dose is 10 to 15 mg/day, divided in two to three doses. The dose can be escalated every 3 days by 5 mg to a maximum dose of 40 mg/day. In children older than 8 years of age, the maximum dose is 60 mg/day. Baclofen is one of a few medications approved for intrathecal administration via implanted flexeril.live pumps and is usually administered to children with spasticity (e.g., cerebral palsy, spinal cord injury). It can also enhance the effects of agents with CNS depressant activity. Older adults appear to have a higher risk for CNS-related adverse reactions, such as hallucinations and confusion, when using cyclobenzaprine.

• The extended-release form typically has a half-life of hours.
• An interaction is when a substance changes the way a drug works.
• Medications other than those listed above may interact with this medication.
• The following information includes only the average doses of this medicine.
• It is also sometimes prescribed off-label to treat fibromyalgia pain.

Your doctor will write the number of refills authorized on your prescription. It isn’t known exactly how this drug works to relax your muscles. It may decrease the signals from your brain that tell your muscles to spasm. If you are not able to swallow the extended-release capsule whole, mix the contents of the capsule with applesauce.

Skeletal muscle relaxants are often prescribed for musculoskeletal conditions including low back pain, neck pain, fibromyalgia, tension headaches, and myofascial pain syndrome. The goals of treatment include managing muscle pain and improving functional status so the patient can return to work or resume previous activities. If cyclobenzaprine is being misused, however, the person may continue to take the medication for much longer and may increase their dose too high, which could lead to dangerous side effects and overdose. Flexeril is an effective pharmacological treatment for muscle spasms and pain, but it can lead to an increased risk of side effects and dependency when mixed with alcohol.

Adverse effects, particularly dizziness and drowsiness, are consistently reported with all skeletal muscle relaxants. The potential adverse effects should be communicated clearly to the patient. Because of limited comparable effectiveness data, choice of agent should be based on side-effect profile, patient preference, abuse potential, and possible drug interactions. Cyclobenzaprine is related structurally and pharmacologically to the tricyclic antidepressants (TCAs). Like other SMRs, cyclobenzaprine produces its effects within the CNS, primarily at the brainstem level.